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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 685-698 doi: 10.1007/s11684-022-0942-1

Abstract: Mechanistically, the knockdown of ACSL5 suppressed the activation of the Wnt/β-cateninpathway by suppressing the palmitoylation modification of Wnt3a.

Keywords： acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract: upregulation of β-catenin and P-Akt expression and the TAC- or ANG II-induced downregulation of GSK-3&

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract: regenerative capacity because of the active participation of various signaling pathways, including WntThe Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multipleIn this regard, Wnt and Notch signaling has gained increased research attention in hair cell regenerationThis review presents the current understanding of the Wnt and Notch signaling pathways in the auditory

Keywords： inner ear     cochlea     hair cell     regeneration     Wnt     Notch     signaling pathways    

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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 705-712 doi: 10.1007/s11684-019-0703-y

Abstract: Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiationHere, we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectionalregulation of Notch1 specifically in Wnt-responsive Lgr5 progenitors during different cochlear developmentWe concluded that the roles of Notch1 in Wnt-responsive Lgr5 cells are unidirectional and stage dependentOur findings improved the understanding of the interactions between Notch and Wnt signaling in cochlear

Keywords： inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 216-228 doi: 10.1007/s11684-008-0042-x

Abstract: Wnt/?deeply understanding of this pathway, more and more genes which contribute to aberrant activation of Wnt

Keywords： interacting     complicated understanding     embryogenesis     activation     organism development    

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Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 143-151 doi: 10.1007/s11684-016-0451-1

Abstract: regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt

Keywords： utricle     hair cell     regeneration     Atoh1     Notch     Wnt    

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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: By using the TOPFlash system we demonstrated that miR-148b could activate Wnt/β-catenin pathway andThese results were considered to indicate that miR-148b could activate the Wnt/β-catenin signal pathway

Keywords： miR-148b     hair follicle     proliferation     NFAT5     Wnt10b    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: Wnt/β-catenin signaling is essential for gastrointestinal development and homeostasis, and its dysregulationAxin1 negatively regulates activated Wnt/β-catenin signaling, but little is known regarding its role

Keywords： Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia muciniphila     Wnt    

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Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4,   Pages 343-348 doi: 10.1007/s11705-007-0062-0

Abstract: An oxetane-derived monomer, 3-acryloyloxymethyl-3′-methyloxetane (AMO) was prepared from the reactionof 3-hydromethyl-3-methyloxetane with acryloyl chloride.The cationic ring-opening copolymerization of AMO with another oxetane-derived monomer, 3-(2-(2-(2-methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane (MEMO) was conducted in CHCl solution using BF3 ·OEt/1, 4-butanediol

Keywords： 4-butanediol     2-methoxyethylenoxy     consistent     oxetane-derived     copolymer    

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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: The Sj14-3-3 gene was amplified and subcloned into the expression vector pPICZ?The protein of rSj14-3-3 was prepared and purified and BALB/c mice were immunized which was followedThe Sj14-3-3 gene was expressed and secreted into the medium and its molecular weight was about 35000antibody and rSj14-3-3 had a promising immune reactivity.The recombinant Sj14-3-3 of eukaryotic expression in was successfully harvested.

Keywords： development     challenging     rSj14-3-3     resistance     cultural supernatant    

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第四届高性能编译、计算和通信国际会议(HP3C 2020)

Conference Date: 12 Mar 2020

Conference Place: 广东广州

Administered by: HP3C 2020

FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract:

Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAs a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expressionAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregFOXP3" side effects must be considered when inhibitors to these enzymes are used.

Keywords： Treg     Forkhead box P3 (FOXP3)     Post-translational modification     Autoimmune     Cancer    

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: However, little is known about the function of Lipin3 in triglyceride (TG) metabolism.Hence, we generated Lipin3 heterozygous knockout (Lipin3-heKO) mice and cultured primary hepatocytesto explore the pathophysiological roles of Lipin3 in TG metabolism.Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.We also established a relationship between Lipin3 and mitochondrial dysfunction.

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Engineering 2017, Volume 3, Issue 5,   Pages 653-662 doi: 10.1016/J.ENG.2017.05.013

Abstract: With the rapid advancement of three-dimensional (3D) printing and 3D bioprinting technologies, many researchersThis paper reviews the applications of these 3D printing and 3D bioprinting technologies for the fabricationThis review specifically discusses the state of the art along with new developments and trends in 3Dmedical phantoms, radiologically relevant medical phantoms, and physiological medical phantoms) and 3D

Keywords： 3D printing     3D bioprinting     Medical phantom     Regenerated tissue/organ     Scaffold    

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Title Author Date Type Operation

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Journal Article

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Journal Article

Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Journal Article

Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Journal Article

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

Xiaohan: Traditional Chinese Medicine Talks About Health, Dietary Supplement and Improving Immunity (2020-3-

18 Apr 2022

Conference Videos

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article

第四届高性能编译、计算和通信国际会议(HP3C 2020)

12 Mar 2020

Conference Information

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Journal Article

A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Journal Article